Jumat, 30 Mei 2014

Food Reward Friday

This week's lucky "winner"... Lay's milk chocolate-dipped potato chips!!


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Kung Fu & Qigong in The Songshang Mountains with Shifu Yan Lei


From Friday 31st July 2015  - Friday 28th August 2015 I will be teaching a Shaolin Summer Camp in the Chinese Songshang Mountains, a few kilometers away from the Shaolin Temple. You will train like a Shaolin Monk, three times a day. You will be taught by myself for two, two hour sessions per day then you will do self-training for one session a day. You will train in authentic Shaolin Kung Fu and Qigong.

You can train for a minimum of two weeks or the whole month. The focus will be on training hard! This is not a holiday. There will be the option of visiting the Shaolin Temple for one of the days and visiting the Bodhidharma Cave. 



Sample Schedule:
Most of your training will be done outside. You will start the day with a run up the mountain then come back and do a kung fu session with the emphasis on strength and stamina training, you will then cool down with some Qigong. After you've finished training, breakfast will be served. This is usually steamed bread, congee, pickled vegetables and stir fried vegetables. After breakfast you will rest and we will start our training again mid-morning, with a focus on getting your form and techniques correct. Lunch will be served at 1pm. After lunch it's advisable to sleep to help your body recover from the hard training. In the afternoon you will do self-training. At 6pm we will have dinner. Evenings will be spent reading,  or doing internal training such as Qigong or meditating. 


Who Is Is Suitable For?
Anyone over the age of 18 who has a passion for Shaolin. 

We will be a small group with a maximum of 18 people. The teaching will be done in English.


Do I have to be good at Kung Fu and Qigong?
Beginner's are welcome but not total beginners. It's best to have a basic fitness level and a grounding in kung fu. But no matter what level you are at, you will be training in a non-competitive friendly environment.


Weather:
It's usually between 30 - 36 so we train in the early morning before it gets hot, and we train inside when the weather is at it's hottest. You need to bring lots of training clothes.

PRICE:

£1000 for two weeks. ( about $1520.00 US dollars)
£1500  for one month. ( about $2285.00 US Dollars)
You can start your training in any of those weeks.



What You Get

1) 3 x 2 hour training sessions per day:

2 of your sessions will be taught by myself and one of your sessions will be self-training.


2) Accommodation:

You will stay in a shared room with one other person. The room has an en-suite bathroom and air conditioning.

3) Meals:

All of your meals will be provided. This will be healthy, hearty, Chinese food, locally grown. Due to the rural location we are sorry but we can't give options for specific dietary needs apart from vegetarian.





What you need to provide:

A valid Chinese visa. 

Your flight to China and travel to the venue.

Travel Insurance

Training clothes, running shoes, training shoes, flip flops or sandals, and towels. 

Some pocket money to buy water, and snacks. If you want to visit the Shaolin Temple, you will need to pay the admission fee

Getting There:

The nearest airport to Shaolin Temple is Zhengzhou. The nearest city is Dengfeng. There are regular flights from Beijing to Zhenghou, and it's possible to book them on the day at the airport.

The address is:  China, Henan Province, Dengfeng City, Leijia Ditch, Shaolin Temple International School.

We can arrange pick up and drop off at Zhengzhou airport. The price will be a maximum of £100.00 depending on the number of people. Once you register, we'll try and put you with other people who are traveling to make the cost as low as possible.

The venue is the blue dot on the map.





Payment Details

Payment needs to be made by bank transfer. All payments must be made in full by 30th June. We can only accept currency in sterling pound. 

Cancellations for All Retreats:
  • If you cancel 4 weeks before your arrival date, we will be happy to refund you, but a cancellation fee of £100.00 will be charged plus £100.00 for the application form.
  • If you cancel less than 4 weeks before your arrival date, there is a cancellation fee of 50% of the total contribution of your stay.
  • If you cancel upon or after your arrival date, there is no refund.
Reserve Your Spot:

Please email info@shifuyanlei.co.uk.  We will send you an application form, and a link to pay a non-refundable deposit of £100.00, which will be off-set from your training fee.


Minggu, 25 Mei 2014

Statins worsen heart function in 71% of patients

This study was published in the American Journal of Cardiology 2004 Nov 15;94(10):1306-10
 
Study title and authors:
Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.
Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A.
Heart Failure Institute, Department of Medicine, Advocate Christ Medical Center, University of Illinois/Christ Cardiovascular Disease Fellowship Program, Oak Lawn, Illinois 60453, USA. marc.silver@advocatehealth.com
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15541254

This study evaluated left ventricular diastolic function before and after statin therapy. The study included 14 patients (who met the National cholesterol Education Program's recommendations for initiating pharmacologic therapy), aged 51 - 79 years, who completed three to six months on atorvastatin.

The study found that 71% of the patients had worsening of left ventricular diastolic function after taking statins.

Dr Silver concluded: "For more than a decade, there has been a suggestion of impairment of diastolic function after the administration of statins, and our findings suggest that this may be a common event and potentially a precursor to symptoms associated with ventricular dysfunction".

Rabu, 21 Mei 2014

A New Understanding of an Old "Obesity Gene"

As you know if you've been following this blog for a while, obesity risk has a strong genetic component.  Genome-wide association studies (GWAS) attempt to identify the specific locations of genetic differences (single-nucleotide polymorphisms or SNPs) that are associated with a particular trait.  In the case of obesity, GWAS studies have had limited success in identifying obesity-associated genes.  However, one cluster of SNPs consistently show up at the top of the list in these studies: those that are near the gene FTO.

As with many of the genes in our genome, different people carry different versions of FTO.  People with two copies of the "fat" version of the FTO SNPs average about 7 pounds (3 kg) heavier than people with two copies of the "thin" version, and they also tend to eat more calories (1, 2).  

Despite being the most consistent hit in these genetic studies, FTO has remained a mystery.  As with most obesity-associated genes, it's expressed in the brain and it seems to respond somewhat to nutritional status.  Yet its function is difficult to reconcile with a role in weight regulation: 
  • It's an enzyme that removes methyl groups from RNA, which doesn't immediately suggest a weight-specific function.
  • It's not primarily expressed in the brain or in body fat, but in all tissues.
  • Most importantly, as far as we know, the different versions of the gene do not result in different tissue levels of FTO, or different activity of the FTO enzyme, so it's hard to understand how they would impact anything at all.  
An important thing to keep in mind is that GWAS studies don't usually pinpoint specific genes.  Typically, they tell us that obesity risk is associated with variability in a particular region of the genome.  If the region corresponds to the location of a single gene, it's a pretty good guess that the gene is the culprit.  However, that's not always the case...

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Senin, 19 Mei 2014

Join Healthy World Cafe for lunch Wednesday, May 28!

Spring is bringing an abundance of fresh produce from local farms!

Photo courtesy of Flickr user Woodley Wonderworks

Celebrate with us and join us for lunch from 11:30 a.m. to 1:30 p.m. Wednesday, May 28, at First Moravian Church, 41 N. Duke St., York, where we'll be serving up delicious, locally sourced eats. Check out our menu!

Menu: 
-- Farmers harvest chicken soup
-- Lentil soup with coconut
-- Spring carrot, radish and quinoa salad with herbed avocado
-- Wheatberry salad with snow peas and carrots
-- Mediterranean hummus served with flatbread
-- Swiss chard and chickpea fritters with yogurt
-- Mushroom and garlic bread pudding with balsamic rhubarb drizzle
-- Rhubarb clafoutis
-- Signature dried fruit and oatmeal cookies

Of course, our menu is always based on what's available from our farmer friends, so check back for updates.

At Healthy World Cafe, we always feature our "eat what you want, pay how you can" philosophy. The ability to pay should never be a barrier to accessing delicious, unprocessed, healthy food.
Housekeeping items worth noting:

-- PARKING: When coming to the cafe for our Wednesday lunches, please DO NOT park in the private lots surrounding First Moravian Church.  You may park on the street (metered), or you may park at First Presbyterian Church at E. Market and N. Queen streets in the un-numbered, yellow-lined parking spots, and
please include a sign on your dashboard to indicate you are a Healthy World Cafe volunteer. Then, walk one block west down Clarke Avenue to First Moravian (and enter on north side)!

-- TAKE OUT: Take out orders for lunch are available by e-mailing your selections (by 10 a.m. May 28) to healthyworldcafe(at)gmail(dot)com.

-- VOLUNTEERING: In order to better respect our volunteers' time, we split the Wednesday lunch into two volunteer shifts: 9 a.m. to 1 p.m., and noon to 3 p.m. Feel free, of course, to sign up for both shifts, if you wish.
And, since this month's lunch falls the week of Memorial Day, we'll forgo our Monday-night prep to allow everyone to enjoy their three-day weekend!

Here's a breakdown of our volunteer needs for this month's lunch:

-- 6 to 9 p.m. Tuesday, May 27 -- Food prep at First Moravian Church. If you're able, join us earlier and help us get a jump start on prep! We'll have volunteers prepping from 3 to 9 p.m.
 -- 9 a.m. to 3 p.m. Wednesday, May 28 -- Food prep and serving at FMC. We're now splitting our lunch days into two volunteer shifts to better respect our volunteers' time: 9 a.m. to 1 p.m., and noon to 3 p.m. Feel free to sign up for both, if you wish. If you can't work a full shift (say, you can be there 10 to 2, but not as early as 9), please email sarah.e.chain(at)gmail(dot)com and let us know when to expect you!

Jumat, 16 Mei 2014

Low cholesterol increases the risk of death by 75% after a heart attack

This study was published in the European Heart Journal 2001 Nov;22(22):2085-103
 
Study title and authors:
Assessment of absolute risk of death after myocardial infarction by use of multiple-risk-factor assessment equations: GISSI-Prevenzione mortality risk chart.
Marchioli R, Avanzini F, Barzi F, Chieffo C, Di Castelnuovo A, Franzosi MG, Geraci E, Maggioni AP, Marfisi RM, Mininni N, Nicolosi GL, Santini M, Schweiger C, Tavazzi L, Tognoni G, Valagussa F; GISSI-Prevenzione Investigators.
Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI), Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Italy.
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/11686666

This study investigated the risk factors for death in patients after they had suffered a heart attack. The study included 11,324 men and women from the GISSI-Prevenzione trial who were followed for four years.

Regarding cholesterol levels, the study found that those with the lowest cholesterol, under 190 mg/dL (4.91 mmol/L), had a 75% increased risk of death compared to those with the highest cholesterol, over 245 mg/dL (6.3 mmol/L).

Minggu, 11 Mei 2014

Possible mechanisms of how statins cause diabetes

This paper was published in Metabolism 2014 Feb 25

Study title and authors:
Statin treatment and new-onset diabetes: A review of proposed mechanisms.
Brault M, Ray J, Gomez YH, Mantzoros CS, Daskalopoulou SS
Department of Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/24641882

Brault notes that new-onset diabetes has been observed in clinical trials and meta-analyses involving statin therapy. Brault discusses the mechanisms that may be involved between statins and diabetes.

(a) Statins affect insulin secretion through direct, indirect or combined effects on calcium channels in pancreatic β-cells.
(b) Statins reduce the expression of glucose transporter 4 (GLUT 4). GLUT 4 is a protein that transports glucose from the bloodstream into cells. Reduced GLUT 4 in response to statins results in hyperglycemia (high blood sugar) and hyperinsulinemia (excess levels of insulin in the blood).
(c) Statin therapy decreases other important molecules such as coenzyme Q10, farnesyl pyrophosphate, geranylgeranyl pyrophosphate, and dolichol; their depletion leads to reduced intracellular signaling.
(d) Statins interference with intracellular insulin signaling pathways via inhibition of necessary phosphorylation events (phosphorylation influences protein enzymes) and reduction of small GTPase action (GTPases are key proteins in many critical biological processes such as hormonal and sensory signals, and the protein building ribosomes). 
(e) Statins can decrease levels of peroxisome proliferator activated receptor gamma and CCAAT/enhancer-binding protein which regulate glucose levels.
(f) Statins may also diminish levels of leptin and adiponectin which also play a role in regulating glucose levels.