This study was published in the Journal of Cardiothoracic Surgergy 2012 Jul 13;7:39
Study title and authors:
Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients.
Study title and authors:
Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients.
Hinz J, Gehoff P, Schotola H, Hosseini MT, Didilis VN, Jebran AF, Gehoff A, Wiese CH, Schulz EG, Schoendube FA, Popov AF.
Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22533985
Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22533985
This study set out to investigate the effect of statin therapy on patients undergoing cardiac surgery with cardiopulmonary bypass. (Cardiopulmonary bypass is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the body). The study included 478 patients who stayed in hospital for an average of 25 days. They were divided into (i) statin taking group (ii) non statin group.
The study found:
(a) Patients taking statins had a 42% increased risk of death whilst in hospital compared to patients not taking statins.
(b) The statin taking group had a significant 16% lower Systemic Vascular Resistance Index compared to the non statin group. (A decrease of Systemic Vascular Resistance Index is evidence for systemic inflammation).
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