Sabtu, 15 Januari 2011

Gluten, coeliac disease and cancer

Published in Med Wieku Rozwoj. 2002 Jul-Sep;6(3):227-32.

Cancer in children with celiac disease. Gluten-sensitive enteropathy in a boy operated for Wilms tumour.
Hozyasz KK, Milanowski A.
Klinika Pediatrii, Instytut Matki i Dziecka, 01-211Warszawa, ul. Kasprzaka 17a, Poland. khozyasz@alpha.net.pl

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12637777
 
In adults untreated coeliac disease (CD) is associated with a wide variety of malignant complications. The overall mortality in CD is approximately twice that of the general population. The excess deaths are due mainly to intestinal cancer. In Europe, only 26 cases of CD and cancer in children have been published. There is evidence that cancer and CD in children are underreported.
 
The paper reported a case of kidney cancer (Wilms tumour) in a child who developed CD. Gluten was introduced in his diet at age of 12 months. He developed vomiting, abdominal distention and organ damage. Up to the age of 16 months he had lost 1500 g and coeliac crisis was diagnosed. Symptoms improved rapidly when a gluten free diet was initiated, and 4 years later, clinical and blood antibodies findings were normal.

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