Clofibrate more than doubles the risk of fatal stroke

Published in the Annals of Internal Medicine July 15, 1993 vol. 119 no. 2 136-145

Cholesterol Reduction and the Risk for Stroke in Men. A Meta-Analysis of Randomized, Controlled Trials
David Atkins, MD, MPH; Bruce M. Psaty, MD, PhD; Thomas D. Koepsell, MD, MPH; W. T. Longstreth, MD, MPH; and Eric B. Larson, MD, MPH
The Cardiovascular Health Research Unit and Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington.

This study can be accessed at: http://www.annals.org/content/119/2/136.abstract
 
The author found that when lowering cholesterol through modified diets or medications there was a general tendency for it to increase the risk of fatal stroke, especically with the drug clofibrate, which more than doubled the risk of fatal stroke.

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