Synthetic food colorings linked to ADHD

Published in the J PEDIATR 1994;125:691-8

Synthetic food coloring and behavior: A dose response effect in a double-blind, placebo-controlled, repeated-measures study
Katherine S. Rowe, MBBS, MPH, Dip Ed(Lond), FRACP, Kenneth J. Rowe, BA(Hons), MSc(Lond)

This study can be accessede at: http://www.jpeds.com/article/S0022-3476(94)70059-1/abstract
 
The premise of the study was to establish whether there is an association between the ingestion of synthetic food colorings and behavioral change in children referred for assessment of "hyperactivity" (ADHD).
 
200 children were included in a 6-week open trial of a diet free of synthetic food coloring. The parents of 150 children reported behavioral improvement with the diet, and deterioration on the introduction of foods noted to contain synthetic coloring.
 
Rowe noted that the higher the synthetic food colouring in the diet, the more effect it had on behaviour.

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